Chemistry-to-gene screens in Caenorhabditis elegans.
نویسندگان
چکیده
The nematode worm Caenorhabditis elegans is a genetic model organism linked to an impressive portfolio of fundamental discoveries in biology. This free-living nematode, which can be easily and inexpensively grown in the laboratory, is also a natural vehicle for screening for drugs that are active against nematode parasites. Here, we show that chemistry-to-gene screens using this animal model can define targets of antiparasitic drugs, identify novel candidate drug targets and contribute to the discovery of new drugs for treating human diseases.
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ورودعنوان ژورنال:
- Nature reviews. Drug discovery
دوره 4 4 شماره
صفحات -
تاریخ انتشار 2005